CHEMGRID MOLECULE CARD
METHYL 7-DESHYDROXYPYROGALLIN-4-CARBOXYLATE
METHYL 7-DESHYDROXYPYROGALLIN-4-CARBOXYLATE in ChemGrid: 205 screened assays, 95 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00201505
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00201505
- Molecular formula
- C13H10O6
- CAS registry number
- 77-41-8
- InChIKey
- DQWQITFUWFBXON-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Methyl 3,4,6-trihydroxy-5-oxobenzo[7]annulene-8-carboxylate
Stored SMILES
COC(=O)C1C=C(O)C(=O)c2c(O)c(O)ccc2C=1Matched external records: PubChem 153273977
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 95 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| BY4741 | Spectrum | 4932 | -30.89 |
| DEP1 | Spectrum | 4932 | -24.22 |
| cnb1-2nd | Spectrum | 4932 | -21.64 |
| CNB1 | Spectrum | 4932 | -20.12 |
| KRE1 | Spectrum | 4932 | -19.72 |
| SLT2 | Spectrum | 4932 | -19.55 |
| TEP1 | Spectrum | 4932 | -18.99 |
| NBP2 | Spectrum | 4932 | -18.01 |
| SMI1 | Spectrum | 4932 | -17.90 |
| ypt6-2nd | Spectrum | 4932 | -17.08 |
| mad1 | Spectrum | 4932 | -16.53 |
| Arp1 | Spectrum | 4932 | -16.01 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| PTPN11 · Tyrosine-protein phosphatase non-receptor type 11 | ChEMBL | PTP3 YER075C (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| VDR · Vitamin D3 receptor | ChEMBL | No stored yeast mapping |
| ATG4B · Cysteine protease ATG4B | ChEMBL analogue | ATG4 YNL223W (ortholog_one2many) |
| GPR35 · G-protein coupled receptor 35 | ChEMBL analogue | No stored yeast mapping |
| groL · GroEL/GroES | ChEMBL analogue | No stored yeast mapping |
| PTPN11 · Tyrosine-protein phosphatase non-receptor type 11 | ChEMBL analogue | PTP3 YER075C (ortholog_many2many) |
| RNASEH1 · Ribonuclease H1 | ChEMBL analogue | RNH1 YMR234W (ortholog_one2one) |
| Tlr2 · Toll-like receptor 1/2 | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete METHYL 7-DESHYDROXYPYROGALLIN-4-CARBOXYLATE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.