CHEMGRID MOLECULE CARD
7,8-DIHYDROXYFLAVONE
7,8-DIHYDROXYFLAVONE in ChemGrid: 205 screened assays, 20 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00201315
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00201315
- Molecular formula
- C15H10O4
- CAS registry number
- 38183-03-8
- InChIKey
- COCYGNDCWFKTMF-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- 7,8-Dihydroxyflavone
Stored SMILES
Oc1ccc2C(=O)C=C(Oc2c1O)c1ccccc1Matched external records: PubChem 1880
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 20 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| ypt6 | SPECMTS3 | 4932 | -9.47 |
| SMI1 | Spectrum | 4932 | -9.36 |
| rgp1 | SPECMTS3 | 4932 | -8.78 |
| sec22 | Spectrum | 4932 | -8.06 |
| BY4741 | Spectrum | 4932 | -6.74 |
| rom2 | Spectrum | 4932 | -6.72 |
| ric1-2nd | Spectrum | 4932 | -6.70 |
| ypt6-2nd | Spectrum | 4932 | -6.59 |
| ric1 | Spectrum | 4932 | -6.12 |
| arf1 | Spectrum | 4932 | -5.83 |
| cdc73 | Spectrum | 4932 | -5.31 |
| Bck1 | Spectrum | 4932 | -5.22 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| IKBKB · Inhibitor of nuclear factor kappa-B kinase subunit beta | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| NTRK2 · BDNF/NT-3 growth factors receptor | ChEMBL | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| VDR · Vitamin D3 receptor | ChEMBL | No stored yeast mapping |
| ACHE · Acetylcholinesterase | ChEMBL analogue | No stored yeast mapping |
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL analogue | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| ALOX12 · Polyunsaturated fatty acid lipoxygenase ALOX12 | ChEMBL analogue | No stored yeast mapping |
| Alox15 · Arachidonate 12-lipoxygenase | ChEMBL analogue | No stored yeast mapping |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL analogue | No stored yeast mapping |
| Alox15b · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| CA12 · Carbonic anhydrase 12 | ChEMBL analogue | No stored yeast mapping |
| CA4 · Carbonic anhydrase 4 | ChEMBL analogue | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL analogue | No stored yeast mapping |
| CBR1 · Carbonyl reductase [NADPH] 1 | ChEMBL analogue | YIR035C (ortholog_many2many); YIR036C (ortholog_many2many) |
| CSNK2B · Casein kinase 2 | ChEMBL analogue | No stored yeast mapping |
| CYP19A1 · Aromatase | ChEMBL analogue | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| CYP1B1 · Cytochrome P450 1B1 | ChEMBL analogue | No stored yeast mapping |
| CYP2C19 · Cytochrome P450 2C19 | ChEMBL analogue | DIT2 YDR402C (ortholog_one2many) |
| DPP4 · Dipeptidyl peptidase 4 | ChEMBL analogue | DAP2 YHR028C (ortholog_one2one) |
| ESR2 · Estrogen receptor beta | ChEMBL analogue | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL analogue | HDA1 YNL021W (ortholog_one2one) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL analogue | No stored yeast mapping |
First 30 of 38 target records; open the interactive profile for further evidence.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 7,8-DIHYDROXYFLAVONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.