CHEMGRID MOLECULE CARD
HYDROCOTOIN
HYDROCOTOIN in ChemGrid: 512 screened assays, 11 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00201081
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00201081
- Molecular formula
- C15H14O4
- InChIKey
- RVXZNIXBABAEQZ-UHFFFAOYSA-N
- Libraries
- Spectrum, SpectrumTMP
- Other recorded names
- (2-Hydroxy-4,6-dimethoxy-phenyl)-phenyl-methanone
Stored SMILES
COc1cc(O)c(C(=O)c2ccccc2)c(OC)c1Matched external records: PubChem 3646534
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
512 measurements across 512 distinct library–species–strain assays; 11 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| HAL24h | SpectrumTMP | 4932 | -21.61 |
| DHA18h | SpectrumTMP | 4932 | -13.75 |
| FAS18h | SpectrumTMP | 4932 | -13.52 |
| NIF18h | SpectrumTMP | 4932 | -12.27 |
| mck1 | Spectrum | 4932 | -11.49 |
| AVM18h | SpectrumTMP | 4932 | -9.87 |
| DAM18h | SpectrumTMP | 4932 | -7.39 |
| HAL18h | SpectrumTMP | 4932 | -6.26 |
| FKA18h | SpectrumTMP | 4932 | -5.47 |
| SAM18h | SpectrumTMP | 4932 | -5.03 |
| cdc73 | Spectrum | 4932 | -4.72 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADORA3 · Adenosine receptor A3 | ChEMBL analogue | No stored yeast mapping |
| AR · Androgen receptor | ChEMBL analogue | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| CBX1 · Chromobox protein homolog 1 | ChEMBL analogue | No stored yeast mapping |
| CHRM1 · Muscarinic acetylcholine receptor M1 | ChEMBL analogue | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| CYP2C19 · Cytochrome P450 2C19 | ChEMBL analogue | DIT2 YDR402C (ortholog_one2many) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL analogue | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL analogue | No stored yeast mapping |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL analogue | AYR1 YIL124W (ortholog_one2one) |
| HTT · Huntingtin | ChEMBL analogue | No stored yeast mapping |
| Lipe · Hormone-sensitive lipase | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL analogue | No stored yeast mapping |
| RORC · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| SLC6A2 · Sodium-dependent noradrenaline transporter | ChEMBL analogue | No stored yeast mapping |
| TBXA2R · Thromboxane A2 receptor | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete HYDROCOTOIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.