CHEMGRID MOLECULE CARD

2,6-DIMETHOXYQUINONE

2,6-DIMETHOXYQUINONE in ChemGrid: 205 screened assays, 2 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE00200413

Explore activity & SONAR

Chemical structure of 2,6-DIMETHOXYQUINONE — Stored molecular structure

205Screened assays

2Significant assay responses

4Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE00200413
Molecular formula: C8H8O4
CAS registry number: 35069-70-6
InChIKey: OLBNOBQOQZRLMP-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: 2,6-Dimethoxy-1,4-Benzoquinone

Stored SMILES

COc1cc(=O)cc(OC)c1=O

Matched external records: PubChem 68262

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 2 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
sac3	SPECMTS3	4932	-6.01
ref2	SPECMTS3	4932	5.17

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
HKDC1 · Hexokinase HKDC1	ChEMBL	No stored yeast mapping
Rorc · Nuclear receptor ROR-gamma	ChEMBL	No stored yeast mapping
Txnrd1 · Thioredoxin reductase 1, cytoplasmic	ChEMBL	TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many)
VDR · Vitamin D3 receptor	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete 2,6-DIMETHOXYQUINONE research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.