ChemGrid

CHEMGRID MOLECULE CARD

4--HYDROXYCHALCONE

4--HYDROXYCHALCONE in ChemGrid: 205 screened assays, 183 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE00200407

Explore activity & SONAR
Chemical structure of 4--HYDROXYCHALCONE
Stored molecular structure
205Screened assays
183Significant assay responses
2Source-labelled target records

Identity and chemistry

ChemGrid identifier
SPE00200407
Molecular formula
C15H12O2
CAS registry number
2657-25-2
InChIKey
UAHGNXFYLAJDIN-UHFFFAOYSA-N
Libraries
Spectrum, SPECMTS3, Spectrum_ED
Other recorded names
4`-HYDROXYCHALCONE; 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one
Stored SMILESOc1ccc(cc1)C(=O)C=Cc1ccccc1

Matched external records: PubChem 94240

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 183 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
StrainLibrarySpecies identifierZ-score
BY4741SPECMTS34932-49.71
aat2SPECMTS34932-48.68
hsp82SPECMTS34932-47.40
hsp104SPECMTS34932-47.35
bck1SPECMTS34932-47.20
lat1SPECMTS34932-46.21
mrc1SPECMTS34932-45.17
BY4741-2ndSPECMTS34932-45.10
vid30SPECMTS34932-44.84
sdh2SPECMTS34932-43.62
gim4SPECMTS34932-43.48
cin8SPECMTS34932-43.22

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

TargetSourceYeast ORF / orthologue
PPO2 · TyrosinaseChEMBLNo stored yeast mapping
TM4SF5 · Transmembrane 4 L6 family member 5ChEMBLNo stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete 4--HYDROXYCHALCONE research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.