CHEMGRID MOLECULE CARD
HAEMATOXYLIN
HAEMATOXYLIN in ChemGrid: 205 screened assays, 13 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00200010
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00200010
- Molecular formula
- C16H14O6
- CAS registry number
- 517-28-2
- InChIKey
- WZUVPPKBWHMQCE-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- 7,11b-dihydrobenz(b)indeno(1,2-d)pyran-3,4,6a,9,10(6H)-pentol
Stored SMILES
Oc1cc2CC3(O)COc4c(O)c(O)ccc4C3c2cc1OMatched external records: PubChem 10603
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 13 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| fet3 | SPECMTS3 | 4932 | -9.08 |
| SMI1 | Spectrum | 4932 | -7.66 |
| top1-2nd | Spectrum | 4932 | -7.51 |
| PPZ1 | Spectrum | 4932 | -7.13 |
| PPH21 | Spectrum | 4932 | -6.01 |
| FKS1 | Spectrum | 4932 | -5.80 |
| cnb1-2nd | Spectrum | 4932 | -5.46 |
| KRE1 | Spectrum | 4932 | -5.33 |
| BY4741 | Spectrum | 4932 | -4.86 |
| DEP1 | Spectrum | 4932 | -4.59 |
| NBP2 | Spectrum | 4932 | -4.44 |
| Arp1 | Spectrum | 4932 | -4.43 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Large T antigen | ChEMBL | No stored yeast mapping |
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL | No stored yeast mapping |
| GAA · Lysosomal alpha-glucosidase | ChEMBL | ROT2 YBR229C (ortholog_one2many) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| L3MBTL1 · Lethal(3)malignant brain tumor-like protein 1 | ChEMBL | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| pfk · ATP-dependent 6-phosphofructokinase | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| TGR · Thioredoxin glutathione reductase | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL analogue | No stored yeast mapping |
| FEN1 · Flap endonuclease 1 | ChEMBL analogue | RAD27 YKL113C (ortholog_one2one) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL analogue | AYR1 YIL124W (ortholog_one2one) |
| IDE · Insulin-degrading enzyme | ChEMBL analogue | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL analogue | YJR119C (ortholog_one2many) |
| mazF · Endoribonuclease toxin MazF | ChEMBL analogue | No stored yeast mapping |
| POLH · DNA polymerase eta | ChEMBL analogue | RAD30 YDR419W (ortholog_one2one) |
| POLK · DNA polymerase kappa | ChEMBL analogue | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| SMAD3 · Mothers against decapentaplegic homolog 3 | ChEMBL analogue | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL analogue | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| VDR · Vitamin D3 receptor | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete HAEMATOXYLIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.