CHEMGRID MOLECULE CARD
5alpha-ANDROSTAN-3,17-DIONE
5alpha-ANDROSTAN-3,17-DIONE in ChemGrid: 205 screened assays, 59 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE00107108
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE00107108
- Molecular formula
- C19H28O2
- InChIKey
- RAJWOBJTTGJROA-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Androstane-3,17-dione, (5alpha)-
Stored SMILES
CC12CCC(=O)CC1CCC1C2CCC2(C)C1CCC2=OMatched external records: PubChem 443
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 59 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| lat1 | SPECMTS3 | 4932 | -21.42 |
| bck1 | SPECMTS3 | 4932 | -18.74 |
| pop2 | Spectrum | 4932 | -16.45 |
| ypt6 | SPECMTS3 | 4932 | -14.79 |
| NBP2 | Spectrum | 4932 | -14.71 |
| mms22 | SPECMTS3 | 4932 | -13.28 |
| mck1 | Spectrum | 4932 | -11.82 |
| rgp1 | SPECMTS3 | 4932 | -11.77 |
| ccr4 | SPECMTS3 | 4932 | -11.21 |
| ser1 | Spectrum | 4932 | -10.76 |
| ypt6-2nd | Spectrum | 4932 | -10.73 |
| gim4 | SPECMTS3 | 4932 | -10.50 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ache · Acetylcholinesterase | ChEMBL analogue | No stored yeast mapping |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL analogue | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ESR1 · Estrogen receptor | ChEMBL analogue | No stored yeast mapping |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL analogue | No stored yeast mapping |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| RORC · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 5alpha-ANDROSTAN-3,17-DIONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.