CHEMGRID MOLECULE CARD
N1-phenyl-2-{[5-(2-pyridyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]thio}acetamide
N1-phenyl-2-{[5-(2-pyridyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]thio}acetamide in ChemGrid: 71 screened assays, 2 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPB 06987
Explore activity & SONAR![Chemical structure of N1-phenyl-2-{[5-(2-pyridyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]thio}acetamide](/structure-thumbnails/Maybridge/SP/SPB_06987.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- SPB 06987
- Molecular formula
- C15H14N4OS2
- InChIKey
- QQXUHMOOSXZQGF-UHFFFAOYSA-N
- Libraries
- Maybridge, Bioactive
- Other recorded names
- QQXUHMOOSXZQGF-UHFFFAOYSA-N
Stored SMILES
O=C(CSC1SC(NN=1)c1ccccn1)Nc1ccccc1Matched external records: PubChem 2746659
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
71 measurements across 71 distinct library–species–strain assays; 2 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| pdryCG200 | Bioactive | 4932 | 10.51 |
| BY4741-3rd | Bioactive | 4932 | 7.24 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| Hsf1 · Heat shock factor protein 1 | ChEMBL | HSF1 YGL073W (ortholog_many2many); HMS2 YJR147W (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| NS1 · Nonstructural protein 1 | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| TARDBP · TAR DNA-binding protein 43 | ChEMBL | PIN4 YBL051C (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete N1-phenyl-2-{[5-(2-pyridyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]thio}acetamide research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.