CHEMGRID MOLECULE CARD
4-(4-methylphenyl)-2-(4-pyridyl)-1,3-thiazole
4-(4-methylphenyl)-2-(4-pyridyl)-1,3-thiazole in ChemGrid: 71 screened assays, 20 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SEW 05400
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SEW 05400
- Molecular formula
- C15H12N2S
- InChIKey
- WHGCQPQZQBCMTM-UHFFFAOYSA-N
- Libraries
- Maybridge, Bioactive
- Other recorded names
- 4-(4-Methylphenyl)-2-pyridin-4-yl-1,3-thiazole
Stored SMILES
Cc1ccc(cc1)c1csc(n1)c1ccncc1Matched external records: PubChem 715106
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
71 measurements across 71 distinct library–species–strain assays; 20 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| pdryCG200 | Bioactive | 4932 | -20.44 |
| pdryCG196 | Bioactive | 4932 | -17.34 |
| pdryCG196log | Bioactive | 4932 | -16.90 |
| SLT2 | Bioactive | 4932 | -15.50 |
| BY4741-3rd | Bioactive | 4932 | -11.31 |
| HOG1 | Bioactive | 4932 | -10.15 |
| CLN2 | Bioactive | 4932 | -8.60 |
| BCK1 | Bioactive | 4932 | -5.21 |
| GLC7 | Bioactive | 4932 | -5.06 |
| AVO1 | Bioactive | 4932 | -4.92 |
| FCP1 | Bioactive | 4932 | -4.86 |
| SDS22 | Bioactive | 4932 | -4.50 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 4-(4-methylphenyl)-2-(4-pyridyl)-1,3-thiazole research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.