CHEMGRID MOLECULE CARD

1-(4-phenoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione

1-(4-phenoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione in ChemGrid: 18 screened assays, 16 with significant responses. Explore chemical identifiers, strain activity and target evidence.

S 01644

Explore activity & SONAR

Chemical structure of 1-(4-phenoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione — Stored molecular structure

18Screened assays

16Significant assay responses

3Source-labelled target records

Identity and chemistry

ChemGrid identifier: S 01644
Molecular formula: C16H11NO3
InChIKey: VAYJAEOCYWSGBB-UHFFFAOYSA-N
Libraries: Maybridge, Cytotoxic
Other recorded names: 1-(4-Phenoxyphenyl)-1H-pyrrole-2,5-dione

Stored SMILES

O=c1ccc(=O)n1c1ccc(Oc2ccccc2)cc1

Matched external records: PubChem 555841

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

18 measurements across 18 distinct library–species–strain assays; 16 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
TOR2	Cytotoxic	4932	-36.42
pdryCG200	Cytotoxic	4932	-31.78
IRE1	Cytotoxic	4932	-31.21
pdryCG196	Cytotoxic	4932	-28.64
SLT2	Cytotoxic	4932	-28.42
CLN2	Cytotoxic	4932	-25.27
BY4741	Cytotoxic	4932	-21.81
KSP1	Cytotoxic	4932	-21.07
TOR1	Cytotoxic	4932	-20.95
NPR1	Cytotoxic	4932	-14.05
RIO2	Cytotoxic	4932	-10.96
FMP48	Cytotoxic	4932	-7.88

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
Faah · Fatty-acid amide hydrolase 1	ChEMBL	SCS7 YMR272C (ortholog_one2one)
MGLL · Monoglyceride lipase	ChEMBL	YJU3 YKL094W (ortholog_one2one)
RTT109 · Histone acetyltransferase RTT109	ChEMBL	YLL002W (source annotation)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete 1-(4-phenoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.