CHEMGRID MOLECULE CARD
6-bromoquinazolin-4-ol
6-bromoquinazolin-4-ol in ChemGrid: 50 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
RH 00197
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- RH 00197
- Molecular formula
- BrC8H5N2O
- InChIKey
- OVEISJPVPHWEHR-UHFFFAOYSA-N
- Libraries
- Maybridge1000
- Other recorded names
- 6-Bromo-4-hydroxyquinazoline
Stored SMILES
Oc1ncnc2ccc(Br)cc12Matched external records: PubChem 135444905
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
50 measurements across 50 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| AKT2 · RAC-beta serine/threonine-protein kinase | ChEMBL | No stored yeast mapping |
| AKT3 · RAC-gamma serine/threonine-protein kinase | ChEMBL | No stored yeast mapping |
| CHEK1 · Serine/threonine-protein kinase Chk1 | ChEMBL | No stored yeast mapping |
| CSF1R · Macrophage colony-stimulating factor 1 receptor | ChEMBL | No stored yeast mapping |
| EGFR · Epidermal growth factor receptor | ChEMBL | No stored yeast mapping |
| FGFR1 · Fibroblast growth factor receptor 1 | ChEMBL | No stored yeast mapping |
| INSR · Insulin receptor | ChEMBL | No stored yeast mapping |
| KDR · Vascular endothelial growth factor receptor 2 | ChEMBL | No stored yeast mapping |
| PIM3 · Serine/threonine-protein kinase pim-3 | ChEMBL | No stored yeast mapping |
| PLK3 · Serine/threonine-protein kinase PLK3 | ChEMBL | No stored yeast mapping |
| PLK4 · Serine/threonine-protein kinase PLK4 | ChEMBL | No stored yeast mapping |
| TYK2 · Non-receptor tyrosine-protein kinase TYK2 | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 6-bromoquinazolin-4-ol research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.