CHEMGRID MOLECULE CARD
5-chloro-6-methyl-2-(2-pyridyl)pyrimidine-4-thiol
5-chloro-6-methyl-2-(2-pyridyl)pyrimidine-4-thiol in ChemGrid: 18 screened assays, 18 with significant responses. Explore chemical identifiers, strain activity and target evidence.
RDR 03820
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- RDR 03820
- Molecular formula
- C10ClH8N3S
- InChIKey
- OMVHUYAQBLWYAA-UHFFFAOYSA-N
- Libraries
- Maybridge, Cytotoxic
- Other recorded names
- 5-Chloro-6-methyl-2-(2-pyridyl)pyrimidine-4-thiol
Stored SMILES
Cc1nc(nc(S)c1Cl)c1ccccn1Matched external records: PubChem 2725954
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
18 measurements across 18 distinct library–species–strain assays; 18 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| TOR2 | Cytotoxic | 4932 | -32.92 |
| pdryCG200 | Cytotoxic | 4932 | -31.55 |
| pdryCG196 | Cytotoxic | 4932 | -29.67 |
| IRE1 | Cytotoxic | 4932 | -29.51 |
| BY4743 | Cytotoxic | 4932 | -26.22 |
| SLT2 | Cytotoxic | 4932 | -24.40 |
| CLN2 | Cytotoxic | 4932 | -22.85 |
| BY4741 | Cytotoxic | 4932 | -22.85 |
| TOR1 | Cytotoxic | 4932 | -19.51 |
| KSP1 | Cytotoxic | 4932 | -18.54 |
| NNK1 | Cytotoxic | 4932 | -15.21 |
| NPR1 | Cytotoxic | 4932 | -13.21 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL | No stored yeast mapping |
| PLK1 · Serine/threonine-protein kinase PLK1 | ChEMBL | CDC5 YMR001C (ortholog_one2one) |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 5-chloro-6-methyl-2-(2-pyridyl)pyrimidine-4-thiol research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.