CHEMGRID MOLECULE CARD
N1-(1-naphthyl)-2-hydroxybenzamide
N1-(1-naphthyl)-2-hydroxybenzamide in ChemGrid: 71 screened assays, 66 with significant responses. Explore chemical identifiers, strain activity and target evidence.
RDR 01818
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- RDR 01818
- Molecular formula
- C17H13NO2
- InChIKey
- KNDXRSHNJYVDFS-UHFFFAOYSA-N
- Libraries
- Maybridge, Bioactive
- Other recorded names
- N-1-Naphthylsalicylamide
Stored SMILES
Oc1ccccc1C(=O)Nc1cccc2ccccc12Matched external records: PubChem 219324
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
71 measurements across 71 distinct library–species–strain assays; 66 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| pdryCG200 | Bioactive | 4932 | -35.40 |
| pdryCG196log | Bioactive | 4932 | -32.10 |
| pdryCG196 | Bioactive | 4932 | -27.25 |
| HOG1 | Bioactive | 4932 | -19.71 |
| BY4741-3rd | Bioactive | 4932 | -16.12 |
| SLT2 | Bioactive | 4932 | -13.48 |
| CLN2 | Bioactive | 4932 | -12.87 |
| DBF4 | Bioactive | 4932 | -8.67 |
| PFK2 | Bioactive | 4932 | -8.36 |
| MPS1 | Bioactive | 4932 | -7.71 |
| FAR1 | Bioactive | 4932 | -7.69 |
| GLC7 | Bioactive | 4932 | -7.48 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| AHR · Aryl hydrocarbon receptor | ChEMBL analogue | No stored yeast mapping |
| ampC · Beta-lactamase | ChEMBL analogue | No stored yeast mapping |
| GLP1R · Glucagon-like peptide 1 receptor | ChEMBL analogue | No stored yeast mapping |
| HTT · Huntingtin | ChEMBL analogue | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| stx1 · Shiga toxin | ChEMBL analogue | No stored yeast mapping |
| TARDBP · TAR DNA-binding protein 43 | ChEMBL analogue | PIN4 YBL051C (ortholog_many2many) |
| TP53 · Cellular tumor antigen p53 | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete N1-(1-naphthyl)-2-hydroxybenzamide research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.