CHEMGRID MOLECULE CARD
Trimetazidine dihydrochloride
Trimetazidine dihydrochloride in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest871
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest871
- Molecular formula
- C14Cl2H24N2O3
- CAS registry number
- 13171-25-0
- InChIKey
- VYFLPFGUVGMBEP-UHFFFAOYSA-N
- Libraries
- Prestwick
- Other recorded names
- Trimetazidine Dihydrochloride
Stored SMILES
Cl.Cl.COc1ccc(CN2CCNCC2)c(OC)c1OCMatched external records: PubChem 83201
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ampC · Beta-lactamase | ChEMBL | No stored yeast mapping |
| APOBEC3A · DNA dC->dU-editing enzyme APOBEC-3A | ChEMBL | No stored yeast mapping |
| APOBEC3G · DNA dC->dU-editing enzyme APOBEC-3G | ChEMBL | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| CTDSP1 · Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | ChEMBL | PSR2 YLR019W (ortholog_one2many) |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| vpr · Aberrant vpr protein | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Trimetazidine dihydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.