CHEMGRID MOLECULE CARD

Clorgyline hydrochloride

Clorgyline hydrochloride in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

Prest762

Explore activity & SONAR

Chemical structure of Clorgyline hydrochloride — Stored molecular structure

3Screened assays

0Significant assay responses

8Source-labelled target records

Identity and chemistry

ChemGrid identifier: Prest762
Molecular formula: C13Cl3H16NO
CAS registry number: 17780-75-5
InChIKey: BBAZDLONIUABKI-UHFFFAOYSA-N
Libraries: Prestwick

Stored SMILES

Cl.CN(CCCOc1ccc(Cl)cc1Cl)CC#C

Matched external records: PubChem 28767

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
Luciferin 4-monooxygenase	ChEMBL	No stored yeast mapping
ampC · Beta-lactamase	ChEMBL	No stored yeast mapping
HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)]	ChEMBL	AYR1 YIL124W (ortholog_one2one)
KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2	ChEMBL	No stored yeast mapping
KMT2A · Histone-lysine N-methyltransferase 2A	ChEMBL	No stored yeast mapping
MAPT · Microtubule-associated protein tau	ChEMBL	No stored yeast mapping
nfo · Endonuclease 4	ChEMBL	No stored yeast mapping
Rorc · Nuclear receptor ROR-gamma	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Clorgyline hydrochloride research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.