CHEMGRID MOLECULE CARD
Benzbromarone
Benzbromarone in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest709
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest709
- Molecular formula
- Br2C17H12O3
- CAS registry number
- 3562-84-3
- InChIKey
- WHQCHUCQKNIQEC-UHFFFAOYSA-N
- Libraries
- Prestwick
Stored SMILES
CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1Matched external records: PubChem 2333
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ABCC1 · Multidrug resistance-associated protein 1 | ChEMBL | No stored yeast mapping |
| ABCG2 · Broad substrate specificity ATP-binding cassette transporter ABCG2 | ChEMBL | SNQ2 YDR011W (ortholog_many2many); PDR15 YDR406W (ortholog_many2many); PDR11 YIL013C (ortholog_many2many); YNR070W (ortholog_many2many); AUS1 YOR011W (ortholog_many2many); PDR5 YOR153W (ortholog_many2many); PDR10 YOR328W (ortholog_many2many); PDR12 YPL058C (ortholog_many2many) |
| AKR1C1 · Aldo-keto reductase family 1 member C1 | ChEMBL | AAD3 YCR107W (ortholog_many2many); YDL124W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); YMR041C (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| CHRM2 · Muscarinic acetylcholine receptor M2 | ChEMBL | No stored yeast mapping |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL | No stored yeast mapping |
| PPARG · Peroxisome proliferator-activated receptor gamma | ChEMBL | No stored yeast mapping |
| SLC22A12 · Solute carrier family 22 member 12 | ChEMBL | PHO84 YML123C (ortholog_one2many) |
| TTR · Transthyretin | ChEMBL | No stored yeast mapping |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Benzbromarone research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.