CHEMGRID MOLECULE CARD
Colchicine
Colchicine in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest695
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest695
- Molecular formula
- C22H25NO6
- CAS registry number
- 64-86-8
- InChIKey
- IAKHMKGGTNLKSZ-UHFFFAOYSA-N
- Libraries
- Prestwick
- Other recorded names
- N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide
Stored SMILES
COC1=CC=C2C(=CC1=O)C(CCc1cc(OC)c(OC)c(OC)c12)NC(C)=OMatched external records: PubChem 2833
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| KMT2A · Histone-lysine N-methyltransferase 2A | ChEMBL | No stored yeast mapping |
| MITF · Microphthalmia-associated transcription factor | ChEMBL | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL | No stored yeast mapping |
| PAX8 · Paired box protein Pax-8 | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL analogue | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL analogue | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| KMT2A · Histone-lysine N-methyltransferase 2A | ChEMBL analogue | No stored yeast mapping |
| MITF · Microphthalmia-associated transcription factor | ChEMBL analogue | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| PAX8 · Paired box protein Pax-8 | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Colchicine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.