CHEMGRID MOLECULE CARD
Ethacrynic acid
Ethacrynic acid in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest671
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest671
- Molecular formula
- C13Cl2H12O4
- CAS registry number
- 58-54-8
- InChIKey
- AVOLMBLBETYQHX-UHFFFAOYSA-N
- Libraries
- Prestwick
- Other recorded names
- Ethacrynic Acid
Stored SMILES
CCC(=C)C(=O)c1ccc(OCC(O)=O)c(Cl)c1ClMatched external records: PubChem 3278
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Large T antigen | ChEMBL | No stored yeast mapping |
| Akr1b1 · Aldo-keto reductase family 1 member B1 | ChEMBL | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| gst-3 · Glutathione-S-transferase | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| VDR · Vitamin D3 receptor | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Ethacrynic acid research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.