CHEMGRID MOLECULE CARD

(-)-Cinchonidine

(-)-Cinchonidine in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

Prest66

Explore activity & SONAR

Chemical structure of (-)-Cinchonidine — Stored molecular structure

3Screened assays

0Significant assay responses

5Source-labelled target records

Identity and chemistry

ChemGrid identifier: Prest66
Molecular formula: C19H22N2O
CAS registry number: 485-71-2
InChIKey: KMPWYEUPVWOPIM-UHFFFAOYSA-N
Libraries: Prestwick
Other recorded names: Alpha-quinidine

Stored SMILES

OC(C1CC2CCN1CC2C=C)c1ccnc2ccccc21

Matched external records: PubChem 2757

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
GLP1R · Glucagon-like peptide 1 receptor	ChEMBL	No stored yeast mapping
MAPT · Microtubule-associated protein tau	ChEMBL	No stored yeast mapping
TARDBP · TAR DNA-binding protein 43	ChEMBL	PIN4 YBL051C (ortholog_many2many)
TDP1 · Tyrosyl-DNA phosphodiesterase 1	ChEMBL	TDP1 YBR223C (ortholog_one2one)
TPR · Trypanothione reductase	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete (-)-Cinchonidine research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.