CHEMGRID MOLECULE CARD

Norethindrone

Norethindrone in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

Prest646

Explore activity & SONAR

Chemical structure of Norethindrone — Stored molecular structure

3Screened assays

0Significant assay responses

2Source-labelled target records

Identity and chemistry

ChemGrid identifier: Prest646
Molecular formula: C20H26O2
CAS registry number: 68-22-4
InChIKey: VIKNJXKGJWUCNN-UHFFFAOYSA-N
Libraries: Prestwick
Other recorded names: 1-Ethynyl-1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta(a)phenanthren-7-one

Stored SMILES

CC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C

Matched external records: PubChem 4536

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
rep · Replicase polyprotein 1ab	ChEMBL	No stored yeast mapping
rep · Replicase polyprotein 1ab	ChEMBL analogue	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Norethindrone research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.