CHEMGRID MOLECULE CARD
Mefexamide hydrochloride
Mefexamide hydrochloride in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest585
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest585
- Molecular formula
- C15ClH25N2O3
- CAS registry number
- 3413-64-7
- InChIKey
- AXBHPHPHZHAOAK-UHFFFAOYSA-N
- Libraries
- Prestwick
Stored SMILES
Cl.CCN(CC)CCNC(=O)COc1ccc(OC)cc1Matched external records: PubChem 3083802
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ampC · Beta-lactamase | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| HSPA5 · Endoplasmic reticulum chaperone BiP | ChEMBL | No stored yeast mapping |
| PIN1 · Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | ChEMBL | ESS1 YJR017C (ortholog_one2one) |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| TARDBP · TAR DNA-binding protein 43 | ChEMBL | PIN4 YBL051C (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Mefexamide hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.