CHEMGRID MOLECULE CARD
Chlorpromazine hydrochloride
Chlorpromazine hydrochloride in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest58
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest58
- Molecular formula
- C17Cl2H20N2S
- CAS registry number
- 69-09-0
- InChIKey
- FBSMERQALIEGJT-UHFFFAOYSA-N
- Libraries
- Prestwick
- Other recorded names
- Chlorpromazine Hydrochloride
Stored SMILES
Cl.CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12Matched external records: PubChem 6240
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CYP2D6 · Cytochrome P450 2D6 | ChEMBL | No stored yeast mapping |
| DRD2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| GFER · FAD-linked sulfhydryl oxidase ALR | ChEMBL | ERV1 YGR029W (ortholog_one2one) |
| HTR1A · 5-hydroxytryptamine receptor 1A | ChEMBL | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL | No stored yeast mapping |
| nfo · Endonuclease 4 | ChEMBL | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| Adra1a · Alpha-1A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| Adra1b · Adrenergic receptor alpha-1 | ChEMBL analogue | No stored yeast mapping |
| ADRA1D · Alpha-1D adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| Drd1 · D(1A) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| Drd2 · D(2) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| DRD3 · D(3) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| HRH1 · Histamine H1 receptor | ChEMBL analogue | PRP22 YER013W (ortholog_one2one) |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL analogue | No stored yeast mapping |
| Htr2b · Serotonin 2 (5-HT2) receptor | ChEMBL analogue | No stored yeast mapping |
| HTR2C · 5-hydroxytryptamine receptor 2C | ChEMBL analogue | No stored yeast mapping |
| HTR6 · 5-hydroxytryptamine receptor 6 | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Chlorpromazine hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.