CHEMGRID MOLECULE CARD

Niridazole

Niridazole in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

Prest543

Explore activity & SONAR

Chemical structure of Niridazole — Stored molecular structure

3Screened assays

0Significant assay responses

9Source-labelled target records

Identity and chemistry

ChemGrid identifier: Prest543
Molecular formula: C6H6N4O3S
CAS registry number: 61-57-4
InChIKey: RDXLYGJSWZYTFJ-UHFFFAOYSA-N
Libraries: Prestwick

Stored SMILES

[O-][N+](=O)c1sc(nc1)N1CCNC1=O

Matched external records: PubChem 6093

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
CYP1A2 · Cytochrome P450 1A2	ChEMBL	No stored yeast mapping
CYP3A4 · Cytochrome P450 3A4	ChEMBL	No stored yeast mapping
GMNN · Geminin	ChEMBL	No stored yeast mapping
HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2	ChEMBL	No stored yeast mapping
PIN1 · Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	ChEMBL	ESS1 YJR017C (ortholog_one2one)
rep · Replicase polyprotein 1ab	ChEMBL	No stored yeast mapping
SMN1 · Survival motor neuron protein	ChEMBL	No stored yeast mapping
TSHR · Thyrotropin receptor	ChEMBL	No stored yeast mapping
USP1 · Ubiquitin carboxyl-terminal hydrolase 1	ChEMBL	UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Niridazole research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.