CHEMGRID MOLECULE CARD
Tiratricol, 3,3`,5-triiodothyroacetic acid
Tiratricol, 3,3`,5-triiodothyroacetic acid in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest439
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest439
- Molecular formula
- C14H9I3O4
- CAS registry number
- 51-24-1
- InChIKey
- UOWZUVNAGUAEQC-UHFFFAOYSA-N
- Libraries
- Prestwick
- Other recorded names
- Tiratricol, 3,3-,5-triiodothyroacetic acid; Tiratricol
Stored SMILES
OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1Matched external records: PubChem 5803
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL | No stored yeast mapping |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL | No stored yeast mapping |
| GABRA1 · Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 | ChEMBL | No stored yeast mapping |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| PDE4D · 3',5'-cyclic-AMP phosphodiesterase 4D | ChEMBL | No stored yeast mapping |
| PPARG · Peroxisome proliferator-activated receptor gamma | ChEMBL | No stored yeast mapping |
| RXRA · Retinoic acid receptor RXR-alpha | ChEMBL | No stored yeast mapping |
| Slco1c1 · Solute carrier organic anion transporter family member 1C1 | ChEMBL | No stored yeast mapping |
| THRA · Thyroid hormone receptor alpha | ChEMBL | No stored yeast mapping |
| Thrb · Thyroid hormone receptor beta | ChEMBL | No stored yeast mapping |
| ITGB3 · Integrin alpha-V/beta-3 | ChEMBL analogue | No stored yeast mapping |
| PPARG · Peroxisome proliferator-activated receptor gamma | ChEMBL analogue | No stored yeast mapping |
| RXRA · Retinoic acid receptor RXR-alpha | ChEMBL analogue | No stored yeast mapping |
| THRA · Thyroid hormone receptor alpha | ChEMBL analogue | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Tiratricol, 3,3`,5-triiodothyroacetic acid research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.