CHEMGRID MOLECULE CARD
Althiazide
Althiazide in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest43
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest43
- Molecular formula
- C11ClH14N3O4S3
- CAS registry number
- 5588-16-9
- InChIKey
- VGLGVJVUHYTIIU-UHFFFAOYSA-N
- Libraries
- Prestwick
Stored SMILES
NS(=O)(=O)c1cc2c(NC(CSCC=C)NS2(=O)=O)cc1ClMatched external records: PubChem 2122
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ampC · Beta-lactamase | ChEMBL | No stored yeast mapping |
| ATM · Serine-protein kinase ATM | ChEMBL | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| DRD1 · D(1A) dopamine receptor | ChEMBL | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL | HDA1 YNL021W (ortholog_one2one) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Althiazide research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.