CHEMGRID MOLECULE CARD

Fosfosal

Fosfosal in ChemGrid: 3 screened assays, 2 with significant responses. Explore chemical identifiers, strain activity and target evidence.

Prest30

Explore activity & SONAR

Chemical structure of Fosfosal — Stored molecular structure

3Screened assays

2Significant assay responses

10Source-labelled target records

Identity and chemistry

ChemGrid identifier: Prest30
Molecular formula: C7H7O6P
CAS registry number: 6064-83-1
InChIKey: FFKUDWZICMJVPA-UHFFFAOYSA-N
Libraries: Prestwick

Stored SMILES

OC(=O)c1ccccc1OP(O)(O)=O

Matched external records: PubChem 3418

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 2 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
TMPPre001	Prestwick	9606	-4.70
TMPPre002	Prestwick	9606	-4.70

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
Luciferin 4-monooxygenase	ChEMBL	No stored yeast mapping
ALDH1A1 · Aldehyde dehydrogenase 1A1	ChEMBL	ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many)
HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)]	ChEMBL	AYR1 YIL124W (ortholog_one2one)
HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2	ChEMBL	No stored yeast mapping
KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2	ChEMBL	No stored yeast mapping
KDM4E · Lysine-specific demethylase 4E	ChEMBL	YJR119C (ortholog_one2many)
PDE3A · cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A	ChEMBL	No stored yeast mapping
PPARG · Peroxisome proliferator-activated receptor gamma	ChEMBL	No stored yeast mapping
SRC · Proto-oncogene tyrosine-protein kinase Src	ChEMBL	No stored yeast mapping
USP2 · Ubiquitin carboxyl-terminal hydrolase 2	ChEMBL	UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Fosfosal research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.