CHEMGRID MOLECULE CARD
Anabasine
Anabasine in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest181
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest181
- Molecular formula
- C10H14N2
- CAS registry number
- 494-52-0
- InChIKey
- MTXSIJUGVMTTMU-UHFFFAOYSA-N
- Libraries
- Prestwick
- Other recorded names
- (+-)-Anabasine
Stored SMILES
C1CCC(NC1)c1cccnc1Matched external records: PubChem 2181
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Ache · Acetylcholinesterase | ChEMBL | No stored yeast mapping |
| Chrna3 · Neuronal acetylcholine receptor | ChEMBL | No stored yeast mapping |
| CHRNA7 · Neuronal acetylcholine receptor subunit alpha-7 | ChEMBL | No stored yeast mapping |
| CHRNB2 · Neuronal acetylcholine receptor; alpha4/beta2 | ChEMBL | No stored yeast mapping |
| FEN1 · Flap endonuclease 1 | ChEMBL | RAD27 YKL113C (ortholog_one2one) |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| nAChRalpha5 · Nicotinic acetylcholine receptor alpha 5 subunit | ChEMBL | No stored yeast mapping |
| POLB · DNA polymerase beta | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Anabasine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.