CHEMGRID MOLECULE CARD
Diflunisal
Diflunisal in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest168
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest168
- Molecular formula
- C13F2H8O3
- CAS registry number
- 22494-42-4
- InChIKey
- HUPFGZXOMWLGNK-UHFFFAOYSA-N
- Libraries
- Prestwick
Stored SMILES
OC(=O)c1cc(ccc1O)c1ccc(F)cc1FMatched external records: PubChem 3059
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL | No stored yeast mapping |
| ACMSD · 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| CA1 · Carbonic anhydrase 1 | ChEMBL | No stored yeast mapping |
| CA2 · Carbonic anhydrase 2 | ChEMBL | No stored yeast mapping |
| CXCL12 · Stromal cell-derived factor 1 | ChEMBL | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| SLC22A6 · Solute carrier family 22 member 6 | ChEMBL | PHO84 YML123C (ortholog_one2many) |
| TTR · Transthyretin | ChEMBL | No stored yeast mapping |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| ACMSD · 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| CA1 · Carbonic anhydrase 1 | ChEMBL analogue | No stored yeast mapping |
| CA2 · Carbonic anhydrase 2 | ChEMBL analogue | No stored yeast mapping |
| CXCL12 · Stromal cell-derived factor 1 | ChEMBL analogue | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| SLC22A6 · Solute carrier family 22 member 6 | ChEMBL analogue | PHO84 YML123C (ortholog_one2many) |
| TTR · Transthyretin | ChEMBL analogue | No stored yeast mapping |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL analogue | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Diflunisal research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.