CHEMGRID MOLECULE CARD
Pyrvinium pamoate
Pyrvinium pamoate in ChemGrid: 3 screened assays, 3 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest1291
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest1291
- Molecular formula
- C101H98N9O6
- CAS registry number
- 3546-41-6
- InChIKey
- IHCFIFSAVMGJDR-UHFFFAOYSA-L
- Libraries
- Prestwick
- Other recorded names
- 3-carboxy-1-[(3-carboxy-2-oxidonaphthalen-1-yl)methyl]naphthalen-2-olate;tris(2-[2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine)
Stored SMILES
[O-]C(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc32)C([O-])=O)c1O.CN(C)c1ccc2c(ccc(C=Cc3cc(C)n(c3C)c3ccccc3)[n+]2C)c1.CN(C)c1ccc2c(ccc(C=Cc3cc(C)n(c3C)c3ccccc3)[n+]2C)c1.CN(C)c1ccc2c(ccc(C=Cc3cc(C)n(c3C)c3ccccc3)[n+]2C)c1Matched external records: PubChem 54735847
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 3 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| TMPPre003 | Prestwick | 9606 | -10.28 |
| TMPPre001 | Prestwick | 9606 | -7.14 |
| TMPPre002 | Prestwick | 9606 | -7.14 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| AR · Androgen receptor | ChEMBL analogue | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL analogue | YJR119C (ortholog_one2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL analogue | NCR1 YPL006W (ortholog_one2one) |
| NSD1 · Histone-lysine N-methyltransferase, H3 lysine-36 specific | ChEMBL analogue | SET1 YHR119W (ortholog_many2many); SET2 YJL168C (ortholog_many2many) |
| POLK · DNA polymerase kappa | ChEMBL analogue | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| RAB9A · Ras-related protein Rab-9A | ChEMBL analogue | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Pyrvinium pamoate research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.