CHEMGRID MOLECULE CARD
Propofol
Propofol in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest1289
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest1289
- Molecular formula
- C12H18O
- CAS registry number
- 2078-54-8
- InChIKey
- OLBCVFGFOZPWHH-UHFFFAOYSA-N
- Libraries
- Prestwick
Stored SMILES
CC(C)c1cccc(C(C)C)c1OMatched external records: PubChem 4943
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| GABRA1 · GABA-A receptor; agonist GABA site | ChEMBL | No stored yeast mapping |
| GABRA1 · GABA-A receptor; alpha-1/beta-2/gamma-2 | ChEMBL | No stored yeast mapping |
| GABRA1 · GABA-A receptor; alpha-1/beta-3/gamma-2 | ChEMBL | No stored yeast mapping |
| GABRA1 · Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 | ChEMBL | No stored yeast mapping |
| Gabrp · GABA-A receptor; anion channel | ChEMBL | No stored yeast mapping |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| PTGS1 · Prostaglandin G/H synthase 1 | ChEMBL | No stored yeast mapping |
| TRPV1 · Transient receptor potential cation channel subfamily V member 1 | ChEMBL | YVC1 YOR087W (ortholog_one2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Propofol research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.