CHEMGRID MOLECULE CARD
Mephenytoin
Mephenytoin in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest1246
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest1246
- Molecular formula
- C12H14N2O2
- InChIKey
- GMHKMTDVRCWUDX-UHFFFAOYSA-N
- Libraries
- Prestwick
Stored SMILES
CCC1(NC(=O)N(C)C1=O)c1ccccc1Matched external records: PubChem 4060
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADRB1 · Beta-1 adrenergic receptor | ChEMBL | No stored yeast mapping |
| CHRNA4 · Neuronal acetylcholine receptor subunit alpha-4 | ChEMBL | No stored yeast mapping |
| Gabra1 · Gamma-aminobutyric acid receptor subunit alpha-1 | ChEMBL | No stored yeast mapping |
| Grin1 · Glutamate receptor ionotropic, NMDA 1 | ChEMBL | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| KPNB1 · Importin subunit beta-1/Snurportin-1 | ChEMBL | KAP95 YLR347C (ortholog_one2one) |
| OPRK1 · Kappa-type opioid receptor | ChEMBL | No stored yeast mapping |
| PPARG · Peroxisome proliferator-activated receptor gamma | ChEMBL | No stored yeast mapping |
| RAN · GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | ChEMBL | GSP1 YLR293C (ortholog_one2many); GSP2 YOR185C (ortholog_one2many) |
| SLC6A3 · Sodium-dependent dopamine transporter | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Mephenytoin research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.