CHEMGRID MOLECULE CARD
Luteolin
Luteolin in ChemGrid: 3 screened assays, 3 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest122
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest122
- Molecular formula
- C15H10O6
- CAS registry number
- 491-70-3
- InChIKey
- IQPNAANSBPBGFQ-UHFFFAOYSA-N
- Libraries
- Prestwick
Stored SMILES
Oc1cc(O)c2C(=O)C=C(Oc2c1)c1ccc(O)c(O)c1Matched external records: PubChem 5280445
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 3 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| TMPPre001 | Prestwick | 9606 | -6.36 |
| TMPPre002 | Prestwick | 9606 | -6.36 |
| TMPPre003 | Prestwick | 9606 | -5.48 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CA12 · Carbonic anhydrase 12 | ChEMBL | No stored yeast mapping |
| CA4 · Carbonic anhydrase 4 | ChEMBL | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL | No stored yeast mapping |
| CSNK2B · Casein kinase 2 | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| CYP1B1 · Cytochrome P450 1B1 | ChEMBL | No stored yeast mapping |
| DPP4 · Dipeptidyl peptidase 4 | ChEMBL | DAP2 YHR028C (ortholog_one2one) |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| MKNK1 · MAP kinase-interacting serine/threonine-protein kinase 1 | ChEMBL | No stored yeast mapping |
| SLC16A1 · Monocarboxylate transporter 1 | ChEMBL | MCH4 YOL119C (ortholog_many2many); MCH5 YOR306C (ortholog_many2many) |
| TTR · Transthyretin | ChEMBL | No stored yeast mapping |
| CA12 · Carbonic anhydrase 12 | ChEMBL analogue | No stored yeast mapping |
| CA4 · Carbonic anhydrase 4 | ChEMBL analogue | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL analogue | No stored yeast mapping |
| CSNK2B · Casein kinase 2 | ChEMBL analogue | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| CYP1B1 · Cytochrome P450 1B1 | ChEMBL analogue | No stored yeast mapping |
| DPP4 · Dipeptidyl peptidase 4 | ChEMBL analogue | DAP2 YHR028C (ortholog_one2one) |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL analogue | No stored yeast mapping |
| MKNK1 · MAP kinase-interacting serine/threonine-protein kinase 1 | ChEMBL analogue | No stored yeast mapping |
| SLC16A1 · Monocarboxylate transporter 1 | ChEMBL analogue | MCH4 YOL119C (ortholog_many2many); MCH5 YOR306C (ortholog_many2many) |
| TTR · Transthyretin | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Luteolin research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.