CHEMGRID MOLECULE CARD

Clioquinol

Clioquinol in ChemGrid: 3 screened assays, 3 with significant responses. Explore chemical identifiers, strain activity and target evidence.

Prest1204

Explore activity & SONAR

Chemical structure of Clioquinol — Stored molecular structure

3Screened assays

3Significant assay responses

12Source-labelled target records

Identity and chemistry

ChemGrid identifier: Prest1204
Molecular formula: C9ClH5INO
CAS registry number: 130-26-7
InChIKey: QCDFBFJGMNKBDO-UHFFFAOYSA-N
Libraries: Prestwick

Stored SMILES

Oc1c(I)cc(Cl)c2cccnc12

Matched external records: PubChem 2788

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 3 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
TMPPre001	Prestwick	9606	-5.44
TMPPre002	Prestwick	9606	-5.44
TMPPre003	Prestwick	9606	-4.11

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
HSP90	ChEMBL	No stored yeast mapping
ALOX12 · Polyunsaturated fatty acid lipoxygenase ALOX12	ChEMBL	No stored yeast mapping
ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15	ChEMBL	No stored yeast mapping
CYP1A2 · Cytochrome P450 1A2	ChEMBL	No stored yeast mapping
HIF1A · Hypoxia-inducible factor 1-alpha	ChEMBL	No stored yeast mapping
HSP90AA1 · Heat shock protein HSP 90-alpha	ChEMBL	HSC82 YMR186W (ortholog_many2many); HSP82 YPL240C (ortholog_many2many)
LMNA · Prelamin-A/C	ChEMBL	No stored yeast mapping
MMP14 · Matrix metalloproteinase-14	ChEMBL	No stored yeast mapping
NS1 · Nonstructural protein 1	ChEMBL	No stored yeast mapping
Rorc · Nuclear receptor ROR-gamma	ChEMBL	No stored yeast mapping
TDP1 · Tyrosyl-DNA phosphodiesterase 1	ChEMBL	TDP1 YBR223C (ortholog_one2one)
USP2 · Ubiquitin carboxyl-terminal hydrolase 2	ChEMBL	UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Clioquinol research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.