CHEMGRID MOLECULE CARD

Altretamine

Altretamine in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

Prest1192

Explore activity & SONAR

Chemical structure of Altretamine — Stored molecular structure

3Screened assays

0Significant assay responses

9Source-labelled target records

Identity and chemistry

ChemGrid identifier: Prest1192
Molecular formula: C9H18N6
InChIKey: UUVWYPNAQBNQJQ-UHFFFAOYSA-N
Libraries: Prestwick

Stored SMILES

CN(C)c1nc(nc(n1)N(C)C)N(C)C

Matched external records: PubChem 2123

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
Chrm1 · Muscarinic acetylcholine receptor M1	ChEMBL	No stored yeast mapping
CYP1A2 · Cytochrome P450 1A2	ChEMBL	No stored yeast mapping
DRD1 · D(1A) dopamine receptor	ChEMBL	No stored yeast mapping
HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2	ChEMBL	No stored yeast mapping
LMNA · Prelamin-A/C	ChEMBL	No stored yeast mapping
NS1 · Nonstructural protein 1	ChEMBL	No stored yeast mapping
RAN · GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1	ChEMBL	GSP1 YLR293C (ortholog_one2many); GSP2 YOR185C (ortholog_one2many)
THRB · Thyroid hormone receptor beta	ChEMBL	No stored yeast mapping
Txnrd1 · Thioredoxin reductase 1, cytoplasmic	ChEMBL	TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Altretamine research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.