CHEMGRID MOLECULE CARD
Cantharidin
Cantharidin in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
Prest1130
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- Prest1130
- Molecular formula
- C10H12O4
- CAS registry number
- 56-25-7
- InChIKey
- DHZBEENLJMYSHQ-UHFFFAOYSA-N
- Libraries
- Prestwick
- Other recorded names
- Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
Stored SMILES
CC12C3CCC(O3)C1(C)C(=O)OC2=OMatched external records: PubChem 2545
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| APP · Amyloid-beta precursor protein | ChEMBL | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| SNCA · Alpha-synuclein | ChEMBL | No stored yeast mapping |
| Serine-threonine protein phosphatase 2A regulatory subunit | ChEMBL analogue | No stored yeast mapping |
| APP · Amyloid-beta precursor protein | ChEMBL analogue | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL analogue | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| PPM1B · Protein phosphatase 1B | ChEMBL analogue | PTC5 YOR090C (ortholog_one2many) |
| PPP1CA · Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | ChEMBL analogue | PPZ1 YML016C (ortholog_one2many) |
| PPP1CC · Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | ChEMBL analogue | PPZ1 YML016C (ortholog_one2many) |
| PPP5C · Serine/threonine-protein phosphatase | ChEMBL analogue | PPT1 YGR123C (ortholog_one2one) |
| PPP5C · Serine/threonine-protein phosphatase 5 | ChEMBL analogue | PPT1 YGR123C (ortholog_one2one) |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| SNCA · Alpha-synuclein | ChEMBL analogue | No stored yeast mapping |
| TFPI2 · Tissue factor pathway inhibitor 2 | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Cantharidin research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.