CHEMGRID MOLECULE CARD

alpha-Santonin

alpha-Santonin in ChemGrid: 3 screened assays, 2 with significant responses. Explore chemical identifiers, strain activity and target evidence.

Prest1129

Explore activity & SONAR

Chemical structure of alpha-Santonin — Stored molecular structure

3Screened assays

2Significant assay responses

1Source-labelled target records

Identity and chemistry

ChemGrid identifier: Prest1129
Molecular formula: C15H18O3
InChIKey: XJHDMGJURBVLLE-UHFFFAOYSA-N
Libraries: Prestwick
Other recorded names: 3,5a,9-Trimethyl-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione

Stored SMILES

CC1C2CCC3(C)C=CC(=O)C(C)=C3C2OC1=O

Matched external records: PubChem 5156

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 2 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
TMPPre001	Prestwick	9606	-4.20
TMPPre002	Prestwick	9606	-4.20

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
ALOX5 · Polyunsaturated fatty acid 5-lipoxygenase	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete alpha-Santonin research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.