CHEMGRID MOLECULE CARD
PK 11195
PK 11195 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01343
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01343
- Molecular formula
- C21ClH21N2O
- InChIKey
- RAVIZVQZGXBOQO-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Stored SMILES
CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)c1ccccc1ClMatched external records: PubChem 1345
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL | No stored yeast mapping |
| nfo · Endonuclease 4 | ChEMBL | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL | No stored yeast mapping |
| NR1I3 · Nuclear receptor subfamily 1 group I member 3 | ChEMBL | No stored yeast mapping |
| TSPO · Translocator protein | ChEMBL | No stored yeast mapping |
| Benzodiazepine | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete PK 11195 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.