CHEMGRID MOLECULE CARD
GR 4661
GR 4661 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01303
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01303
- Molecular formula
- C23H27N3O2
- Libraries
- Lopac
- Other recorded names
- GR 46611
Stored SMILES
COc1ccc(CNC(=O)C=Cc2ccc3ncc(CCN(C)C)c3c2)cc1Matched external records: PubChem 6160690
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| DRD2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| HTR1A · 5-hydroxytryptamine receptor 1A | ChEMBL | No stored yeast mapping |
| HTR1B · 5-hydroxytryptamine receptor 1B | ChEMBL | No stored yeast mapping |
| HTR1D · 5-hydroxytryptamine receptor 1D | ChEMBL | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| 5-HT1D | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete GR 4661 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.