CHEMGRID MOLECULE CARD
T-1032
T-1032 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01271
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01271
- Molecular formula
- C32H31N3O11S
- InChIKey
- NVGOUBIJVPSVSL-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 3-Isoquinolinecarboxylic acid, 2-(4-aminophenyl)-1,2-dihydro-1-oxo-7-(2-pyridinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-, methyl ester, sulfate (1:1)
Stored SMILES
COC(=O)C1N(C(=O)c2cc(OCc3ccccn3)ccc2C=1c1cc(OC)c(OC)c(OC)c1)c1ccc(N)cc1.OS(O)(=O)=OMatched external records: PubChem 9874535
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL | No stored yeast mapping |
| PDE1A · Phosphodiesterase 1 | ChEMBL | No stored yeast mapping |
| PDE2A · cGMP-dependent 3',5'-cyclic phosphodiesterase | ChEMBL | No stored yeast mapping |
| PDE4A · Phosphodiesterase 4 | ChEMBL | No stored yeast mapping |
| PDE5A · cGMP-specific 3',5'-cyclic phosphodiesterase | ChEMBL | No stored yeast mapping |
| PDE6B · Phosphodiesterase 6 | ChEMBL | No stored yeast mapping |
| PDE V | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete T-1032 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.