CHEMGRID MOLECULE CARD
Tyrphostin AG 34
Tyrphostin AG 34 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01261
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01261
- Molecular formula
- C11H8N2O3
- InChIKey
- DWZFIFZYMHNRRV-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 2-[(3,4-Dihydroxy-5-methoxyphenyl)methylidene]propanedinitrile
Stored SMILES
COc1cc(cc(O)c1O)C=C(C#N)C#NMatched external records: PubChem 667645
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL | No stored yeast mapping |
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL | No stored yeast mapping |
| EGFR · Epidermal growth factor receptor | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL | No stored yeast mapping |
| NFKB1 · Nuclear factor NF-kappa-B p105 subunit | ChEMBL | No stored yeast mapping |
| POLH · DNA polymerase eta | ChEMBL | RAD30 YDR419W (ortholog_one2one) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| Tyrosine kinase | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Tyrphostin AG 34 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.