CHEMGRID MOLECULE CARD
(±)-alpha-Lipoic Acid
(±)-alpha-Lipoic Acid in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01258
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01258
- Molecular formula
- C8H14O2S2
- InChIKey
- AGBQKNBQESQNJD-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- (±)-alpha-Lipoic Acid; alpha Lipoic acid
Stored SMILES
OC(=O)CCCCC1CCSS1Matched external records: PubChem 864
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ACHE · Acetylcholinesterase | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| L3MBTL1 · Lethal(3)malignant brain tumor-like protein 1 | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| nfo · Endonuclease 4 | ChEMBL | No stored yeast mapping |
| POLB · DNA polymerase beta | ChEMBL | No stored yeast mapping |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL | No stored yeast mapping |
| SAE1 · SUMO-activating enzyme | ChEMBL | YHR003C (ortholog_many2many); YKL027W (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| THRB · Thyroid hormone receptor beta | ChEMBL | No stored yeast mapping |
| ACHE · Acetylcholinesterase | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| L3MBTL1 · Lethal(3)malignant brain tumor-like protein 1 | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| nfo · Endonuclease 4 | ChEMBL analogue | No stored yeast mapping |
| POLB · DNA polymerase beta | ChEMBL analogue | No stored yeast mapping |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL analogue | No stored yeast mapping |
| SAE1 · SUMO-activating enzyme | ChEMBL analogue | YHR003C (ortholog_many2many); YKL027W (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| THRB · Thyroid hormone receptor beta | ChEMBL analogue | No stored yeast mapping |
| Pyruvate dehydrogenase | ChemGrid bioactivity_info | No stored yeast mapping |
| ADRA2C · alpha | lopac_target_list | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete (±)-alpha-Lipoic Acid research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.