CHEMGRID MOLECULE CARD
Tyrphostin AG 490
Tyrphostin AG 490 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01243
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01243
- Molecular formula
- C17H14N2O3
- InChIKey
- TUCIOBMMDDOEMM-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
Stored SMILES
Oc1ccc(cc1O)C=C(C#N)C(=O)NCc1ccccc1Matched external records: PubChem 2390
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| AURKB · Aurora kinase B | ChEMBL | IPL1 YPL209C (ortholog_one2many) |
| AXL · Tyrosine-protein kinase receptor UFO | ChEMBL | No stored yeast mapping |
| EEF2K · Eukaryotic elongation factor 2 kinase | ChEMBL | No stored yeast mapping |
| GSK3A · Glycogen synthase kinase-3 alpha | ChEMBL | No stored yeast mapping |
| GSK3B · Glycogen synthase kinase-3 beta | ChEMBL | No stored yeast mapping |
| HIPK4 · Homeodomain-interacting protein kinase 4 | ChEMBL | KNS1 YLL019C (ortholog_many2many) |
| MAP4K2 · Mitogen-activated protein kinase kinase kinase kinase 2 | ChEMBL | CDC15 YAR019C (ortholog_many2many); SSK22 YCR073C (ortholog_many2many); SPS1 YDR523C (ortholog_many2many); STE20 YHL007C (ortholog_many2many); BCK1 YJL095W (ortholog_many2many); CLA4 YNL298W (ortholog_many2many); SSK2 YNR031C (ortholog_many2many); SKM1 YOL113W (ortholog_many2many) |
| MAP4K5 · Mitogen-activated protein kinase kinase kinase kinase 5 | ChEMBL | No stored yeast mapping |
| MARK2 · Serine/threonine-protein kinase MARK2 | ChEMBL | No stored yeast mapping |
| PLK3 · Serine/threonine-protein kinase PLK3 | ChEMBL | No stored yeast mapping |
| PLK4 · Serine/threonine-protein kinase PLK4 | ChEMBL | No stored yeast mapping |
| PRKAA1 · 5'-AMP-activated protein kinase catalytic subunit alpha-1 | ChEMBL | PRR2 YDL214C (ortholog_many2many); KIN1 YDR122W (ortholog_many2many); VHS1 YDR247W (ortholog_many2many); HAL5 YJL165C (ortholog_many2many); PTK2 YJR059W (ortholog_many2many); KKQ8 YKL168C (ortholog_many2many); PTK1 YKL198C (ortholog_many2many); KIN2 YLR096W (ortholog_many2many); NPR1 YNL183C (ortholog_many2many); KIN4 YOR233W (ortholog_many2many); SKS1 YPL026C (ortholog_many2many); YPL141C (ortholog_many2many) |
| JAK2 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Tyrphostin AG 490 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.