CHEMGRID MOLECULE CARD
Trequinsin hydrochloride
Trequinsin hydrochloride in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01238
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01238
- Molecular formula
- C24ClH28N3O3
- InChIKey
- DTCZZBVPTHVXFA-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 4H-Pyrimido[6,1-a]isoquinolin-4-one, 2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-, hydrochloride (1:1)
Stored SMILES
Cl.COc1cc2CCN3C(=O)N(C)C(C=C3c2cc1OC)=Nc1c(C)cc(C)cc1CMatched external records: PubChem 3060974
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ht1 · Hexose transporter 1 | ChEMBL | No stored yeast mapping |
| LmGT2 · Glucose transporter | ChEMBL | No stored yeast mapping |
| SLC2A1 · Solute carrier family 2, facilitated glucose transporter member 1 | ChEMBL | YBR241C (ortholog_many2many); MAL31 YBR298C (ortholog_many2many); RGT2 YDL138W (ortholog_many2many); SNF3 YDL194W (ortholog_many2many); HXT15 YDL245C (ortholog_many2many); MPH2 YDL247W (ortholog_many2many); HXT7 YDR342C (ortholog_many2many); HXT6 YDR343C (ortholog_many2many); HXT3 YDR345C (ortholog_many2many); HXT13 YEL069C (ortholog_many2many); HXT10 YFL011W (ortholog_many2many); VPS73 YGL104C (ortholog_many2many); MAL11 YGR289C (ortholog_many2many); HXT4 YHR092C (ortholog_many2many); HXT1 YHR094C (ortholog_many2many); HXT5 YHR096C (ortholog_many2many); HXT8 YJL214W (ortholog_many2many); HXT9 YJL219W (ortholog_many2many); HXT16 YJR158W (ortholog_many2many); MPH3 YJR160C (ortholog_many2many); GAL2 YLR081W (ortholog_many2many); HXT2 YMR011W (ortholog_many2many); HXT17 YNR072W (ortholog_many2many); HXT11 YOL156W (ortholog_many2many) |
| PDE III | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Trequinsin hydrochloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.