CHEMGRID MOLECULE CARD
PD 98,059
PD 98,059 in ChemGrid: 24 screened assays, 2 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01174
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01174
- Molecular formula
- C16H13NO3
- InChIKey
- QFWCYNPOPKQOKV-UHFFFAOYSA-N
- Libraries
- Lopac
- Other recorded names
- 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Stored SMILES
COc1cccc(c1N)C1Oc2ccccc2C(=O)C=1Matched external records: PubChem 4713
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 2 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| whi5 | Lopac | 4932 | -5.84 |
| SQS1 | Lopac | 4932 | -4.64 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL | HDA1 YNL021W (ortholog_one2one) |
| MAP2K1 · Dual specificity mitogen-activated protein kinase kinase 1 | ChEMBL | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MAPK3 · Mitogen-activated protein kinase; ERK1/ERK2 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many); SKY1 YMR216C (ortholog_many2many) |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL | NCR1 YPL006W (ortholog_one2one) |
| PMP22 · Peripheral myelin protein 22 | ChEMBL | No stored yeast mapping |
| PTGS1 · Prostaglandin G/H synthase 1 | ChEMBL | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| RAF1 · Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) | ChEMBL | No stored yeast mapping |
| THPO · Thrombopoietin | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL analogue | HDA1 YNL021W (ortholog_one2one) |
| MAP2K1 · Dual specificity mitogen-activated protein kinase kinase 1 | ChEMBL analogue | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MAPK3 · Mitogen-activated protein kinase; ERK1/ERK2 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many); SKY1 YMR216C (ortholog_many2many) |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL analogue | NCR1 YPL006W (ortholog_one2one) |
| PMP22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| PTGS1 · Prostaglandin G/H synthase 1 | ChEMBL analogue | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL analogue | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| RAF1 · Serine/threonine-protein kinase RAF and Dual specificity mitogen-activated protein kinase kinase 1 (Raf/MEK) | ChEMBL analogue | No stored yeast mapping |
| THPO · Thrombopoietin | ChEMBL analogue | No stored yeast mapping |
| MEK2 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete PD 98,059 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.