CHEMGRID MOLECULE CARD
SB 216763
SB 216763 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01117
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01117
- Molecular formula
- C19Cl2H12N2O2
- Libraries
- Lopac
Stored SMILES
Cn1cc(c2ccccc12)c1c(=O)nc(=O)c1c1ccc(Cl)cc1ClMatched external records: PubChem 176158
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Cyclin-dependent kinase 1/cyclin B | ChEMBL | No stored yeast mapping |
| Cyclin-dependent kinase 2/cyclin A | ChEMBL | No stored yeast mapping |
| Glycogen synthase kinase-3 | ChEMBL | No stored yeast mapping |
| APOBEC3F · DNA dC->dU-editing enzyme APOBEC-3F | ChEMBL | No stored yeast mapping |
| APOBEC3G · DNA dC->dU-editing enzyme APOBEC-3G | ChEMBL | No stored yeast mapping |
| GSK3A · Glycogen synthase kinase-3 alpha | ChEMBL | No stored yeast mapping |
| GSK3B · Glycogen synthase kinase-3 beta | ChEMBL | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| RPS6KA1 · Ribosomal protein S6 kinase alpha-1 | ChEMBL | No stored yeast mapping |
| GSK-3 | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete SB 216763 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.