CHEMGRID MOLECULE CARD
MK-886
MK-886 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01113
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01113
- Molecular formula
- C27ClH33NNaO2S
- InChIKey
- CBNCIYNCWVGEKJ-UHFFFAOYSA-M
- Libraries
- Lopac
- Other recorded names
- MK886 sodium
Stored SMILES
[Na+].[O-]C(=O)C(C)(C)Cc1n(Cc2ccc(Cl)cc2)c2ccc(cc2c1SC(C)(C)C)C(C)CMatched external records: PubChem 4519262
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX5 · Polyunsaturated fatty acid 5-lipoxygenase | ChEMBL | No stored yeast mapping |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL | No stored yeast mapping |
| FTL · Ferritin light chain | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL | No stored yeast mapping |
| POLH · DNA polymerase eta | ChEMBL | RAD30 YDR419W (ortholog_one2one) |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| TBXAS1 · Thromboxane-A synthase | ChEMBL | No stored yeast mapping |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
| Inhibitor | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete MK-886 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.