CHEMGRID MOLECULE CARD

Ouabain

Ouabain in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

LOPAC 01110

Explore activity & SONAR

Chemical structure of Ouabain — Stored molecular structure

24Screened assays

0Significant assay responses

3Source-labelled target records

Identity and chemistry

ChemGrid identifier: LOPAC 01110
Molecular formula: C29H44O12
InChIKey: LPMXVESGRSUGHW-UHFFFAOYSA-N
Libraries: Lopac
Other recorded names: 3-((6-Deoxyhexopyranosyl)oxy)-1,5,11,14,19-pentahydroxycard-20(22)-enolide

Stored SMILES

CC1OC(OC2CC(O)C3(CO)C4C(O)CC5(C)C(CCC5(O)C4CCC3(O)C2)C2COC(=O)C=2)C(O)C(O)C1O

Matched external records: PubChem 4605

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
rep · Replicase polyprotein 1ab	ChEMBL	No stored yeast mapping
rep · Replicase polyprotein 1ab	ChEMBL analogue	No stored yeast mapping
Na+/K+ ATPase	ChemGrid bioactivity_info	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Ouabain research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.