ChemGrid

CHEMGRID MOLECULE CARD

MK-912

MK-912 in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

LOPAC 01062

Explore activity & SONAR
Chemical structure of MK-912
Stored molecular structure
24Screened assays
0Significant assay responses
4Source-labelled target records

Identity and chemistry

ChemGrid identifier
LOPAC 01062
Molecular formula
C20ClH26N3O2
InChIKey
ALYCEQJIRFYVGE-UHFFFAOYSA-N
Libraries
Lopac
Other recorded names
L-657,743 hydrochloride
Stored SMILESCl.CN1CCC2(CCN3CCc4c(oc5ccccc54)C3C2)N(C)C1=O

Matched external records: PubChem 9976794

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

TargetSourceYeast ORF / orthologue
BLM · RecQ-like DNA helicase BLMChEMBLSGS1 YMR190C (ortholog_one2one)
PMP22 · Peripheral myelin protein 22ChEMBLNo stored yeast mapping
SMN1 · Survival motor neuron proteinChEMBLNo stored yeast mapping
alpha2AChemGrid bioactivity_infoNo stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete MK-912 research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.