CHEMGRID MOLECULE CARD
8-Methoxymethyl-3-isobutyl-1-methylxanthine
8-Methoxymethyl-3-isobutyl-1-methylxanthine in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01036
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01036
- Molecular formula
- C12H18N4O3
- Libraries
- Lopac
Stored SMILES
COCc1nc2N(CC(C)C)C(=O)N(C)C(=O)c2n1Matched external records: PubChem 155806
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Phosphodiesterase 1 [CHEMBL2095150] | ChEMBL | No stored yeast mapping |
| Phosphodiesterase 1 [CHEMBL2097166] | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| PDE1A · Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | ChEMBL | No stored yeast mapping |
| PDE5A · cGMP-specific 3',5'-cyclic phosphodiesterase [CHEMBL1827] | ChEMBL | No stored yeast mapping |
| PDE5A · cGMP-specific 3',5'-cyclic phosphodiesterase [CHEMBL3478] | ChEMBL | No stored yeast mapping |
| PDE I | ChemGrid bioactivity_info | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 8-Methoxymethyl-3-isobutyl-1-methylxanthine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.