CHEMGRID MOLECULE CARD
Luteolin
Luteolin in ChemGrid: 24 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LOPAC 01016
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LOPAC 01016
- Molecular formula
- C15H10O6
- InChIKey
- IQPNAANSBPBGFQ-UHFFFAOYSA-N
- Libraries
- Lopac
Stored SMILES
Oc1cc(O)c2C(=O)C=C(Oc2c1)c1ccc(O)c(O)c1Matched external records: PubChem 5280445
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
24 measurements across 24 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CA12 · Carbonic anhydrase 12 | ChEMBL | No stored yeast mapping |
| CA4 · Carbonic anhydrase 4 | ChEMBL | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL | No stored yeast mapping |
| CSNK2B · Casein kinase 2 | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| CYP1B1 · Cytochrome P450 1B1 | ChEMBL | No stored yeast mapping |
| DPP4 · Dipeptidyl peptidase 4 | ChEMBL | DAP2 YHR028C (ortholog_one2one) |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| MKNK1 · MAP kinase-interacting serine/threonine-protein kinase 1 | ChEMBL | No stored yeast mapping |
| SLC16A1 · Monocarboxylate transporter 1 | ChEMBL | MCH4 YOL119C (ortholog_many2many); MCH5 YOR306C (ortholog_many2many) |
| TTR · Transthyretin | ChEMBL | No stored yeast mapping |
| Avian myoblastosis virus polyprotein II | ChEMBL analogue | No stored yeast mapping |
| Cruzipain | ChEMBL analogue | No stored yeast mapping |
| ABCB1 · ATP-dependent translocase ABCB1 | ChEMBL analogue | MDL1 YLR188W (ortholog_many2many); MDL2 YPL270W (ortholog_many2many) |
| ABCC1 · Multidrug resistance-associated protein 1 | ChEMBL analogue | No stored yeast mapping |
| ABCG2 · Broad substrate specificity ATP-binding cassette transporter ABCG2 | ChEMBL analogue | SNQ2 YDR011W (ortholog_many2many); PDR15 YDR406W (ortholog_many2many); PDR11 YIL013C (ortholog_many2many); YNR070W (ortholog_many2many); AUS1 YOR011W (ortholog_many2many); PDR5 YOR153W (ortholog_many2many); PDR10 YOR328W (ortholog_many2many); PDR12 YPL058C (ortholog_many2many) |
| ACHE · Acetylcholinesterase | ChEMBL analogue | No stored yeast mapping |
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL analogue | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL analogue | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ALOX12 · Polyunsaturated fatty acid lipoxygenase ALOX12 | ChEMBL analogue | No stored yeast mapping |
| Alox15 · Arachidonate 12-lipoxygenase | ChEMBL analogue | No stored yeast mapping |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL analogue | No stored yeast mapping |
| Alox15b · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| AURKA · Aurora kinase A | ChEMBL analogue | No stored yeast mapping |
| AURKB · Aurora kinase B | ChEMBL analogue | IPL1 YPL209C (ortholog_one2many) |
| CA12 · Carbonic anhydrase 12 | ChEMBL analogue | No stored yeast mapping |
| CA4 · Carbonic anhydrase 4 | ChEMBL analogue | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL analogue | No stored yeast mapping |
| CBR1 · Carbonyl reductase [NADPH] 1 | ChEMBL analogue | YIR035C (ortholog_many2many); YIR036C (ortholog_many2many) |
First 30 of 87 target records; open the interactive profile for further evidence.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Luteolin research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.